Adaptive Bayesian Designs for Dose-ranging Drug Trials
نویسندگان
چکیده
منابع مشابه
Bayesian Adaptive Designs for Early Phase Clinical Trials
BAYESIAN ADAPTIVE DESIGNS FOR EARLY PHASE CLINICAL TRIALS Publication No. Chunyan Cai, B.S. Supervisory Professor: Ying Yuan, Ph.D. My dissertation focuses mainly on Bayesian adaptive designs for phase I and phase II clinical trials. It includes three specific topics: (1) proposing a novel two-dimensional dose-finding algorithm for biological agents, (2) developing Bayesian adaptive screening d...
متن کاملAdaptive designs for phase II cross-over dose-finding trials using Bayesian model averaging
Finding the right dose of a novel treatment is one of the most important tasks in early drug development. However, there is often uncertainty about the form of the relationship between dose and patient response at the time that the dose-finding trials are designed. In this presentation we develop Bayesian adaptive designs for Phase II cross-over trials conducted to estimate the minimum effectiv...
متن کاملBootstrap Aggregating Continual Reassessment Method for Dose Finding in Drug-combination Trials1 By
Phase I drug-combination trials are becoming commonplace in oncology. Most of the current dose-finding designs aim to quantify the toxicity probability space using certain prespecified yet complicated models. These models need to characterize not only each individual drug’s toxicity profile, but also their interaction effects, which often leads to multi-parameter models. We propose a novel Baye...
متن کاملAdaptive designs for selecting drug combinations based on efficacy–toxicity response
We propose a new adaptive procedure for dose-finding in clinical trials with combination of two drugs when both efficacy and toxicity responses are available. We model the distribution of this bivariate binary endpoint using the bivariate probit model. The analytic formulae for the Fisher information matrix are obtained, that form the basis for derivation of the locally optimal, minimax, Bayesi...
متن کاملBayesian Adaptive Methods for Clinical Trials of Targeted Agents
This chapter presents general Bayesian concepts and some specific designs for human clinical trials of targeted agents. The designs employ decision rules that use each patient’s protein or gene expression biomarkers, and possibly conventional prognostic variables, to choose an individualized treatment regime that may include one or several targeted agents. The Bayesian rules are sequentially ad...
متن کامل